CNS

  • Interview with Dr. Leslie Citrome14:37

    Interview with Dr. Leslie Citrome

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  • Q&A with CNS Expert, Dr. Leslie Citrome

    Q&A with CNS Expert, Dr. Leslie Citrome

    Leslie Citrome, MD, MPH, a member of WCG’s Scientific Leadership Team, shared his insights during a recent conversation with Mark Opler, MD, PhD, chief research officer at WCG-MedAvante-ProPhase.

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  • Q&A with CNS Expert, Dr. Christoph U. Correll

    Q&A with CNS Expert, Dr. Christoph U. Correll

    Christoph U. Correll, MD, a member of WCG’s Scientific Leadership Team, shared his thoughts in a recent conversation with Mark Opler, MD, PhD, chief research officer at WCG-MedAvante-ProPhase.

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  • Interview with Dr. Cristoph Correll14:37

    Interview with Dr. Cristoph Correll

    Christoph Correll, MD, a member of WCG’s Scientific Leadership Team, shares his thoughts on the most important trends in CNS clinical trials and what lies ahead in 2019

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  • Genetic Counselors at the Forefront of Helping Researchers Brace for the "Silver Tsunami" of CNS Disorders

    Genetic Counselors at the Forefront of Helping Researchers Brace for the "Silver Tsunami" of CNS Disorders

    An aging population is triggering a “silver tsunami” of neurodegenerative diseases like Alzheimer’s and Parkinson. At the same time, precision medicine holds great promise for many CNS disorders.

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  • CNS Drugs Take Longer to Develop, Win Approval

    CNS Drugs Take Longer to Develop, Win Approval

    CNS drugs take 20% longer to develop and about 19 months (36%) longer on average than other meds to win FDA approval after clinical trials

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  • eCOA: Keep it Simple, Exec Argues

    eCOA: Keep it Simple, Exec Argues

    Nearly half of all clinical trials still use paper as the primary - or even sole - source of records while barely a quarter of trials use eCOA or ePRO

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  • Positive and Negative Syndrome Scale (PANSS) Training: Challenges, Solutions, and Future Directions

    Positive and Negative Syndrome Scale (PANSS) Training: Challenges, Solutions, and Future Directions

    In this article, the authors review the methods for ensuring reliability of the PANSS as well as a proposed trajectory for its use in the future.

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  • Prospective, Head-to-Head Study of Three Computerized Neurocognitive Assessment Tools Part 2: Utility for Assessment of Mild Traumatic Brain

    Prospective, Head-to-Head Study of Three Computerized Neurocognitive Assessment Tools Part 2: Utility for Assessment of Mild Traumatic Brain

    The aim of this study was to evaluate the reliability and validity of three computerized neurocognitive assessment tools (CNTs; i.e., ANAM, DANA, and ImPACT) for assessing mild traumatic brain injury.

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  • Acute Clinical Predictors of Symptom Recovery in Emergency Department Patients with Uncomplicated Mild Traumatic Brain Injury or Non-Traumat

    Acute Clinical Predictors of Symptom Recovery in Emergency Department Patients with Uncomplicated Mild Traumatic Brain Injury or Non-Traumat

    The purpose of this study was to investigate the predictors of symptom recovery in a prospective sample of emergency department trauma patients with either mTBI or non-mTBI injuries.

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  • Detecting cognitive changes in preclinical Alzheimer’s disease: A review of its feasibility

    Detecting cognitive changes in preclinical Alzheimer’s disease: A review of its feasibility

    Significant progress has been made in characterizing the biological changes occurring in preclinical Alzheimer’s disease (AD).

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  • Is cognitive decline measurable in preclinical Alzheimer’s disease?

    Is cognitive decline measurable in preclinical Alzheimer’s disease?

    As Alzheimer’s disease (AD) drug development moves to earlier, preclinical stages of disease, clinicians, trialists, and regulators have wrestled with the question of how to detect cognitive change...

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  • A systematic review of potential long-term effects of sport-related concussion

    A systematic review of potential long-term effects of sport-related concussion

    Objective: Systematic review of possible long-term effects of sports-related concussion in retired athletes.

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  • Recommended cognitive outcomes in preclinical Alzheimer’s disease - Consensus statement from the European Prevention of Alzheimer’s Dementia

    Recommended cognitive outcomes in preclinical Alzheimer’s disease - Consensus statement from the European Prevention of Alzheimer’s Dementia

    The resulting consensus statement provides recommendations for both future drug trials and research into preclinical Alzheimer’s disease.

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  • Multiple comorbid neuropathologies in the setting of Alzheimer’s disease neuropathology and implications for drug development

    Multiple comorbid neuropathologies in the setting of Alzheimer’s disease neuropathology and implications for drug development

    This review will cover the neuropathologic basis of dementia, provide clinical perspectives on multiple pathologies, and discuss therapeutics and biomarkers targeting overlapping pathologies...

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