Detecting cognitive changes in preclinical Alzheimer’s disease: A review of its feasibility

Abstract

Significant progress has been made in characterizing the biological changes occurring in preclinical Alzheimer’s disease (AD). Cognitive dysfunction has been viewed, however, as a late-stage phenomenon, despite increasing evidence that changes may be detected in the decades preceding dementia. In the absence of comprehensive evidence-based guidelines for preclinical cognitive assessment, longitudinal cohort and neuroimaging studies have been reviewed to determine the temporal order and brain biomarker correlates of specific cognitive functions. Episodic memory decline was observed to be the most salient cognitive function, correlating with high levels of amyloid deposition and hypoconnectivity across large-scale brain networks. Prospective studies point to early decline in both episodic and semantic memory processing as well as executive functions in the predementia period. The cognitive tests have, however, been principally those used to diagnose dementia. New procedures are required which target more finely the medial temporal lobe subregions first affected by clinically silent AD pathology.

About the Author

Dr. Christopher Randolph, PhD, ABPP-CN | Chief Scientific Officer

Dr. Christopher Randolph is Chief Scientific Officer at MedAvante/Prophase and Clinical Professor of Neurology at Loyola University Medical Center. Dr. Randolph has extensive experience in CNS clinical trials work, as an investigator, consultant and creator and supervisor of rater training programs for a large number of Phase II and Phase III multinational studies in Alzheimer’s disease and other neurodegenerative conditions; schizophrenia; stroke; hepatic encephalopathy; and traumatic brain injury.

Follow on Linkedin More Content by Dr. Christopher Randolph, PhD, ABPP-CN | Chief Scientific Officer
Previous Flipbook
The Essential and Most Commonly Overlooked Step in Optimizing Study Enrollment
The Essential and Most Commonly Overlooked Step in Optimizing Study Enrollment

Next Flipbook
Is cognitive decline measurable in preclinical Alzheimer’s disease?
Is cognitive decline measurable in preclinical Alzheimer’s disease?

As Alzheimer’s disease (AD) drug development moves to earlier, preclinical stages of disease, clinicians, t...

Request a Genetics in Clinical Trials training session

What You'll Learn