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Most Recent Flipbooks
Best Practices in Site Feasibility Studies Can Set the Stage for a Healthy Trial
Positive and Negative Syndrome Scale (PANSS) Training: Challenges, Solutions, and Future Directions
In this article, the authors review the methods for ensuring reliability of the PANSS as well as a proposed trajectory for its use in the future.
Data-Driven Site Selection: Accelerating Your Trials Through Predictive Site Modeling
Prospective, Head-to-Head Study of Three Computerized Neurocognitive Assessment Tools Part 2: Utility for Assessment of Mild Traumatic Brain
The aim of this study was to evaluate the reliability and validity of three computerized neurocognitive assessment tools (CNTs; i.e., ANAM, DANA, and ImPACT) for assessing mild traumatic brain injury.
Applied Clinical Trials:Single IRB Review for All Multicenter Clinical Trials
Acute Clinical Predictors of Symptom Recovery in Emergency Department Patients with Uncomplicated Mild Traumatic Brain Injury or Non-Traumat
The purpose of this study was to investigate the predictors of symptom recovery in a prospective sample of emergency department trauma patients with either mTBI or non-mTBI injuries.
The Essential and Most Commonly Overlooked Step in Optimizing Study Enrollment
Detecting cognitive changes in preclinical Alzheimer’s disease: A review of its feasibility
Significant progress has been made in characterizing the biological changes occurring in preclinical Alzheimer’s disease (AD).
Is cognitive decline measurable in preclinical Alzheimer’s disease?
As Alzheimer’s disease (AD) drug development moves to earlier, preclinical stages of disease, clinicians, trialists, and regulators have wrestled with the question of how to detect cognitive change...
Clinical Researcher: Myths and Realities of Placebo Response - A 21st Century Prescription
A systematic review of potential long-term effects of sport-related concussion
Objective: Systematic review of possible long-term effects of sports-related concussion in retired athletes.
Contract Delays and Legal Negotiations Become a Growing Concern in Global Site Selection
Recommended cognitive outcomes in preclinical Alzheimer’s disease - Consensus statement from the European Prevention of Alzheimer’s Dementia
The resulting consensus statement provides recommendations for both future drug trials and research into preclinical Alzheimer’s disease.
Multiple comorbid neuropathologies in the setting of Alzheimer’s disease neuropathology and implications for drug development
This review will cover the neuropathologic basis of dementia, provide clinical perspectives on multiple pathologies, and discuss therapeutics and biomarkers targeting overlapping pathologies...
Early Chart Reviews Can Provide Steady Flow of Potential Study Subjects, Experts Say
An Executive Summary: Speed, Efficiency, and Accuracy in Site Contracts and Payments
Personalized Medicine Requires Personalized Measurement
Case Study: Site Selection & Feasibility
IRB Advisor: Newest Oncology Studies Raise Ethical, Other Questions for IRBs
Clinical Researcher: Applying ISO9001 to the IRB Process